22nd Century Group adds Clear Street as sales agent for $18.8 million stock program

22nd Century Group, Inc. filed a new prospectus supplement on October 28, 2026 adding Clear Street LLC as a sales agent under its at-the-market stock sales agreement. On October 28, 2026, the company entered into an amendment to the Sales Agreement to add Clear Street LLC as a Sales Agent, and the prospectus supplement was filed solely to add Clear Street LLC in that role.¹

The filing amends and supplements earlier prospectus supplements dated April 10, 2026, May 1, 2026 and October 23, 2026, which relate to the offer and sale of common stock pursuant to the Sales Agreement with Needham & Company, LLC dated November 4, 2025.¹ The underlying program still covers up to $18,800,000 of common stock sold through the Sales Agreement.¹

22nd Century Group's stock trades on the Nasdaq Capital Market under the symbol "XXII," and closed at $0.105 per share on October 27, 2026.¹ That marks a decline from the $0.2157 closing price reported in the prior supplement dated October 23, 2026, when the company disclosed an aggregate market value of outstanding common stock held by non-affiliates of approximately $70.7 million, based on 19,202,198 shares outstanding, of which 8 shares were held by affiliates, using a $3.68 per share price from the closing on August 24, 2026.²

That October 23, 2026 supplement had also noted that under SEC rules, the company cannot sell securities in a public primary offering exceeding one-third of its public float in any 12-month period while that float remains below $75,000,000, and it had sold $4.7 million of securities under that limit during the prior 12 calendar months.² A related 8-K dated October 23, 2026 disclosed that during October 2026 the company raised roughly $4.7 million in gross proceeds through the sale of 15,785,757 shares under the Sales Agreement.³ That report was signed by Lawrence Firestone, the company's Chief Executive Officer.³