Gemelli registers interventional EV trial mapping vascular complications in systemic sclerosis
A new study, EVOLVE-SSc, will track extracellular vesicles across circulatory sites to link EV profiles with vascular disease severity in systemic sclerosis patients.
The registry lists a single new item for the week concerning systemic sclerosis and extracellular vesicle biology.
- "EVOLVE-SSc" (NCT07717060), an interventional study sponsored by Fondazione Policlinico Universitario Agostino Gemelli IRCCS, is not yet recruiting, with an estimated start date of 2026-09-01. The study proposes characterizing circulating EVs at specific vascular locations accessible through acral vessels and during clinically indicated procedures such as right heart catheterization and coronary angiography, procedures recommended for the assessment of PAH in patients with SSc that pose no additional risk.1 Sampling will occur at the pulmonary artery and ascending aorta, reflecting pulmonary circulation and cardiac EV exchange, and the peripheral radial artery and cephalic vein, representing EV exchange within the acral circulation.1
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